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KMID : 0644120090220010125
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Journal of Oriental Gynecology
2009 Volume.22 No. 1 p.125 ~ p.139
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Increasing Effects of Apoptosis When Co-treated Scutellaria barbata D. Don. with Anti-cancer Drugs
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Nam Ju-Young
Sung Jung-Suk
Jun Hyun-Ik
Lee Jeong-Won
Kwon Su-Kyung
Kim Dong-Il
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Abstract
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Purpose: This experiment was designed to find out increasing effects of S. barbata. co-treatment with anti-cancer drugs at cancer cell’s growth inhibition effect.
Methods: Divergent observational study of the S. barbata. co-treatment with Cisplatin treatment on HeLa cell. Cell viability using MTT assay, Cell Culture and Cytotoxicity Studies, Cell Cycle Analysis, Annexin V-FITC/PI assay, Cell morphological assessment, PARP cleavage using Western blotting analysis when HeLa cell were co-treated with Cisplatin and Scutellaria Barbata extracts.
Results: When HeLa cell were co-treated with Cisplatin and Scutellaria Barbata extracts, we found out viability of HeLa cell, changing in the distribution of cell cycle, Annexin V-FITC staining, DAPI staining, PARP clavage protein assay by Western-blot. So Scutellaria Barbata extracts have increased apoptosis
Conclusion: When co-treated Scutellaria Barbata extracts with anti-cancer drugs, the anti-cancer effects were increased. We still not sure which constituent apoptosis at cancer cells and activates anti-cancer effects suppressing, but we believe that it’ll be revealed here after with following experiments.
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KEYWORD
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Scutellaria Batatae D. Don, Cisplatin, HeLa cell, Apoptosis
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